V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
… Genome-wideassociationstudies (GWAS) involve testing genetic variants across the genomes of many individuals to identify genotype–phenotype associations. GWAS have …
… the genome-wideassociation … studies that are designed and executed with low statistical power and inadequate quality control. Here, in the context of genome-wideassociationstudies …
… , which include both LINKAGE MAPPING and genome-wideassociationstudies. The main … present arguments as to why genome-wideassociationstudies might be advantageous for …
… We will focus here on the genome-wideassociation study or GWAS that measures and analyzes DNA sequence variations from across the human genome in an effort to identify genetic …
L Kruglyak - Nature Reviews Genetics, 2008 - nature.com
The recent crop of results from genome-wideassociationstudies might seem like a sudden development. However, this blooming follows a long germination period during which the …
A Ziegler, IR König… - … Journal: Journal of …, 2008 - Wiley Online Library
… human genome for association is a novel and promising approach to unravelling the genetic basis of complex genetic diseases. In these genome-wideassociationstudies (GWAs), …
… that can be used to carry out genome-wideassociationstudies (GWASs). The availability of … the discovery of new associations that have been replicated in multiple studies. However, it …
… We present a novel framework for relationship inference, Kinship-based INference for Genome-wideassociationstudies (KING), together with a rapid algorithm for relationship inference …
… genome-wideassociation (GWA) studies. An example is shown to illustrate that many genes in a susceptibility pathway may show evidence of association, although not genome-wide …